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目的观察苯磺酸氨氯地平片联合马来酸依那普利片治疗老年单纯收缩期高血压的临床疗效。方法将120例老年单纯收缩期高血压患者随机分为A、B、C 3组,每组40例,其中,A组给予苯磺酸氨氯地平片,B组给予马来酸依那普利片,C组给予苯磺酸氨氯地平片联合马来酸依那普利片,规律用药3个月,监测用药前后的收缩压(SBP)、舒张压(DBP)、尿微量白蛋白(mALB)、舒张期左心室后壁厚度(LVPWT)的水平变化。对比3组降压效果。结果 C组的血压治疗显效率及总有效率均明显高于A、B组(P<0.05)。3组患者经过治疗SBP、DBP均低于治疗前,差异均有统计学意义(P<0.05);A组治疗后SBP低于B组,差异有统计学意义(P<0.05);C组治疗后SBP、DBP均低于A、B组,差异均有统计学意义(P<0.05)。3组患者经过治疗舒张期LVPWT较治疗前均有所下降,差异均有统计学意义(P<0.05)。B组与C组治疗后mALB均下降,且2组mALB、舒张期LVPWT均较A组下降显著,差异具有统计学意义(P<0.05)。结论苯磺酸氨氯地平片联合马来酸依那普利片治疗老年单纯收缩期高血压疗效优于单药治疗。
Objective To observe the clinical efficacy of amlodipine besylate combined with enalapril maleate in the treatment of elderly isolated systolic hypertension. Methods A total of 120 elderly patients with isolated systolic hypertension were randomly divided into A, B and C groups, 40 patients in each group. A group received amlodipine besylate tablets, B group received enalapril maleate The patients in group C were given amlodipine besylate together with enalapril maleate for 3 months. The systolic blood pressure (SBP), diastolic blood pressure (DBP), urinary microalbumin (mALB) ), Left ventricular posterior wall thickness (LVPWT) level changes. Compare 3 groups antihypertensive effect. Results The effective rate and total effective rate of blood pressure treatment in group C were significantly higher than those in group A and B (P <0.05). The SBP and DBP in the three groups were lower than those before treatment (P <0.05). The SBP in group A was lower than that in group B, the difference was statistically significant (P <0.05) After SBP, DBP were lower than the A, B group, the difference was statistically significant (P <0.05). The LVPWT of the three groups after treatment was lower than that before treatment, the differences were statistically significant (P <0.05). The levels of mALB decreased in both groups B and C, and the mALB and diastolic LVPWT in two groups decreased significantly compared with those in group A, with statistical significance (P <0.05). Conclusion Amlodipine besylate tablets and enalapril maleate tablets are superior to monotherapy in the treatment of isolated systolic hypertension in the elderly.