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目的探讨胎盘多肽注射液联合化疗治疗中晚期口腔癌的有效性和安全性。方法选取2010年10月至2012年8月间行化疗的中晚期口腔癌患者128例,随机分为胎盘多肽联合化疗的治疗组(65例)和单纯化疗的对照组(63例)。治疗组患者于化疗前1d开始注射胎盘多肽8ml,连用7d,28d为1个周期,共用4个周期。评价治疗效果、患者全身状态和药物毒性等。结果治疗组和对照组患者的有效率分别为55.4%和53.9%,差异无统计学意义(P>0.05)。治疗组患者化疗后QOL、KPS评分高于对照组,差异有统计学意义(P<0.05)。治疗组患者化疗后白细胞下降程度低于对照组,恶心呕吐、口腔黏膜炎发生率也明显低于对照组,差异有统计学意义(P<0.05)。两组患者其他外周血象指标及腹泻、脱发、肝功能异常等不良反应发生率相似,差异无统计学意义(P>0.05)。结论中晚期口腔癌患者化疗期间,联合应用胎盘多肽注射液能够辅助治疗肿瘤,并具有较好的安全性,值得进一步在临床推广应用。
Objective To investigate the effectiveness and safety of placental peptide injection combined with chemotherapy in the treatment of advanced oral cancer. Methods 128 patients with advanced oral cancer undergoing chemotherapy between October 2010 and August 2012 were randomly divided into treatment group (65 cases) treated with placental peptide combined with chemotherapy and control group (63 cases) treated with chemotherapy alone. Patients in the treatment group began to inject 8ml of placental peptide 1d before chemotherapy and continued for 7 days and 28 days for 1 cycle, sharing 4 cycles. Evaluation of treatment, the patient’s general condition and drug toxicity. Results The effective rates of the treatment group and the control group were 55.4% and 53.9%, respectively, with no significant difference (P> 0.05). The QOL and KPS scores of patients in the treatment group after chemotherapy were higher than those in the control group, with significant difference (P <0.05). After treatment, the leukopenia in the treatment group was lower than that in the control group. The incidence of nausea and vomiting and oral mucositis in the treatment group was also significantly lower than that in the control group. The difference was statistically significant (P <0.05). The other two groups of patients with peripheral blood indicators and diarrhea, hair loss, liver dysfunction and other adverse reactions were similar, the difference was not statistically significant (P> 0.05). Conclusions During the chemotherapy of advanced oral cancer patients, combined application of placental peptide injection can assist in the treatment of cancer, and has good safety, which deserves further clinical application.