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目的探讨中国人群IgE高亲和力受体β链(FcεRIβ)基因-6843G/A多态性与哮喘易感性的关系。方法检索PubMed、Embase、中国学术期刊网全文数据库(CNKI)、万方数据检索系统及维普数据库,收集研究中国人群FcεRIβ基因-6843G/A多态性与哮喘易感性关系的文献进行Meta分析,末次检索时间为2009年10月1日。病例组和对照组基因型分布的比值比(OR)及95%CI为效应指标,应用RevMan 4.2.8软件对各研究原始数据进行统计学分析并检验异质性,采用STATA10.0软件检验发表偏倚。结果根据纳入排除标准,共有9篇文献研究-6843G/A多态性位点,G携带者(GG+GA)的哮喘发病风险较AA野生型纯合子(AA)增加49%(OR=1.49,95%CI1.01~2.22)。亚组分析显示,G携带者成年发病的风险明显增高(OR=1.83,95%CI1.32~2.52),而儿童发病风险无显著性差异(OR=1.19,95%CI0.68~2.08)。结论中国人群FcεRIβ基因-6843G/A多态性与哮喘易感性密切相关,突变子G携带者的哮喘发病风险较高。
Objective To investigate the relationship between -6843G / A polymorphism of IgE high affinity receptor β chain (FcεRIβ) gene and susceptibility to asthma in Chinese population. Methods PubMed, Embase, CNKI, Wanfang Data Retrieval System and VIP database were searched for Meta-analysis of the literature that studied the relationship between -6843G / A polymorphism of FcεRIβ gene and susceptibility to asthma in Chinese population. Retrieved on October 1, 2009. The odds ratio (OR) and 95% CI of the genotype distribution in the case group and the control group were used as the effect indexes. The original data of each study were statistically analyzed and the heterogeneity was tested by using RevMan 4.2.8 software. The data were verified by STATA10.0 software test Bias. Results According to the exclusion criteria, there were 9 articles on the -6843G / A polymorphism locus. The risk of asthma in G carriers (GG + GA) was 49% higher than that in AA wild-type homozygotes (OR = 1.49, 95% CI 1.01 ~ 2.22). Subgroup analysis showed that the risk of adult carriers of G carriers was significantly higher (OR = 1.83, 95% CI: 1.32-2.52), but no significant difference in children’s risk of onset (OR = 1.19, 95% CI: 0.68-2.08). Conclusion The -6843G / A polymorphism of FcεRIβ gene in Chinese population is closely related to the susceptibility to asthma. The incidence of asthma in mutant G carriers is high.