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目的研究环氧化酶-2在鼻咽癌中的表达,探讨其与鼻咽癌的增生、浸润及转移的关系。方法在26例鼻咽癌及相应癌旁组织和10例正常鼻咽部黏膜组织中,应用逆转录-聚合酶链反应(RT-PCR)方法检测环氧化酶-2 mRNA的表达。结果在鼻咽癌组织中环氧化酶-2 mRNA高表达,在正常鼻咽部黏膜环氧化酶-2 mRNA中低表达,差异具有统计学意义(P<0.01)。结论环氧化酶-2与鼻咽癌的生长、浸润及转移有密切关系。
Objective To study the expression of cyclooxygenase-2 in nasopharyngeal carcinoma (NPC) and to explore its relationship with the proliferation, invasion and metastasis of NPC. Methods The expression of cyclooxygenase-2 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) in 26 cases of nasopharyngeal carcinoma, adjacent paracancerous tissues and 10 cases of normal nasopharyngeal mucosa. Results The expression of cyclooxygenase-2 mRNA in nasopharyngeal carcinoma was significantly lower than that in normal nasopharyngeal mucosa. The difference was statistically significant (P <0.01). Conclusions Cyclooxygenase-2 is closely related to the growth, invasion and metastasis of nasopharyngeal carcinoma.