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对20例用左旋门冬酰胺酶(L-ASP)治疗的淋巴系统恶性肿瘤患儿进行治疗前后血Ca、P、PT、KPTT、血糖、血淀粉酶、总蛋白、白蛋白和眼压的前瞻性观察,发现L-ASP治疗后1周较治疗前血Ca、P、总蛋白、白蛋白均有明显降低,1例发生糖尿病,1例治疗后眼压有较明显增高。结论:在L-ASP治疗前后,应对血总蛋白、白蛋白、血Ca、P、血糖做常规监测;对临床有出血倾向者,动态监测PT、KPTT;有腹痛者,动态监测血淀粉酶;有条件者进行眼压测定,有利于及时发现药物不良反应并及时治疗。
Prospects of blood Ca, P, PT, KPTT, blood glucose, serum amylase, total protein, albumin and intraocular pressure before and after treatment of 20 children with lymphatic system malignancy treated with L-Asparaginase During the first week after L-ASP treatment, the levels of Ca, P, total protein and albumin in blood were significantly decreased in 1 week after treatment. Diabetes mellitus occurred in 1 case and was significantly higher in 1 case after treatment. Conclusion: Before and after treatment with L-ASP, blood total protein, albumin, blood Ca, P, blood glucose should be routinely monitored; for those with clinical bleeding tendency, PT and KPTT should be dynamically monitored; Conditional evaluation of intraocular pressure is conducive to timely detection of adverse drug reactions and timely treatment.