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目的 肝硬化的形成一般认为是由纤维组织增生、胶原纤维合成增加所致 ,但肝内循环受阻 ,出现门脉高压的病因仍需探讨。方法 收集 85例肝硬化肝组织作HE、组化和免疫组化染色 ,镜检观察病变特点。结果 肝组织切片内除见一般肝硬化病理特点外 ,在门脉区内均可见到小血管内存在血栓和机化 ,并有明显炎细胞浸润血管 ,而且病变程度与临床分型诊断和病型轻重密切相关。结论 失代偿期肝硬化腹水形成除与肝内慢性炎症有关外 ,门脉区内小血管炎、栓塞和机化是其重要病因。
Purpose The formation of cirrhosis of the liver is generally believed to be caused by the proliferation of fibrous tissue and the increase of synthesis of collagen fibers. However, the intrahepatic circulation is blocked and the etiology of portal hypertension still needs to be explored. Methods Totally 85 liver cirrhosis samples were collected for HE staining, histochemistry and immunohistochemistry staining. The pathological changes were observed microscopically. Results In addition to the pathological features of liver cirrhosis in the liver slice, there were thrombus and mechanization of small blood vessels in the portal area, with obvious inflammatory cell infiltration of blood vessels, and the degree of disease and clinical classification of the diagnosis and type Closely related to severity. Conclusions In addition to the chronic intrahepatic inflammation, the formation of ascites due to decompensated cirrhosis is associated with vasculitis, embolization and mechanization in the portal area.