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目的:介绍胆微透析技术及其在药学研究中的应用。方法:检索、阅读近年来国内外的相关文献,并进行分析、归纳。结果:综述了胆微透析技术的基本原理、特点及影响因素,并重点介绍了其在肠肝循环药物以及经胆囊排泄药物的药动学研究中的应用。结论:胆微透析技术在药学研究中具有不可替代的作用,但仍有不足之处,尚需继续研究不断改进完善。
Objective: To introduce the microdialysis technique and its application in pharmacy research. Methods: To search and read the relevant literature at home and abroad in recent years, and to analyze and summarize. Results: The basic principle, characteristics and influential factors of biliary microdialysis were reviewed. The application of the drug in intestinal enterohepatic circulation and pharmacokinetics of excretion through the gallbladder was also introduced. Conclusion: Gallbladder dialysis technology plays an irreplaceable role in pharmacy research, but there are still some shortcomings. It is necessary to continue to study and improve continuously.