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目的:检测环氧化酶-2(Cox-2)、间隙连接蛋白43(Cx43)、雌激素受体(ER)、孕激素受体(PR)在子宫内膜癌(EC)组织中的表达,探讨四者在EC发生、发展中的作用及相互关系。方法:采用免疫组织化学染色,检测Cox-2、Cx43、ER、PR在正常子宫内膜、不典型增生内膜、EC的表达,分析四者与EC临床病理特征的关系及四者之间的相关性。结果:①Cox-2在正常子宫内膜、不典型增生内膜、EC组织中的阳性表达率明显递增,差异有统计学意义;Cx43、ER、PR在正常子宫内膜、不典型增生内膜、EC组织中的阳性表达率明显递减,差异有统计学意义;②在EC中,Cox-2、Cx43的阳性表达与组织病理分级有关,与手术病理分期、肌层浸润深度、淋巴结转移无关;ER、PR的阳性表达与组织病理分级、手术病理分期、淋巴结转移有关,与肌层浸润深度无关;③在EC组织中Cox-2表达与ER及PR负相关,Cx43表达与ER及PR正相关,Cox-2与Cx43负相关。结论:Cox-2的表达增加及Cx43表达缺失在EC的发生、发展过程中起重要作用,参与了EC的发生及发展;ER、PR在EC中表达水平愈低,肿瘤的分化程度愈低,预后愈差。
Objective: To detect the expression of Cox-2, connexin 43 (Cx43), estrogen receptor (ER) and progesterone receptor (PR) in endometrial carcinoma (EC) tissues , To explore the role of the four in the occurrence and development of EC and their relationship. Methods: The expressions of Cox-2, Cx43, ER and PR in normal endometrium, atypical hyperplasia endometrium and EC were detected by immunohistochemistry. The relationship between them and the clinical and pathological features of EC was analyzed. Correlation. Results: ① The positive expression rates of Cox-2 in normal endometrium, atypical hyperplasia endometrium and EC tissues were significantly increased, the difference was statistically significant; Cx43, ER, PR in normal endometrium, atypical hyperplasia, The positive expression rates of Cox-2 and Cx43 in EC were significantly correlated with histopathological grade, but not with pathological stage, depth of myometrial invasion and lymph node metastasis. ER The positive expression of PR was correlated with histopathological grade, surgical pathologic stage and lymph node metastasis, but not with the depth of myometrial invasion. (3) The expression of Cox-2 was negatively correlated with ER and PR in EC tissues. The expression of Cx43 was positively correlated with ER and PR, Cox-2 was negatively correlated with Cx43. CONCLUSION: The increased expression of Cox-2 and the loss of Cx43 play an important role in the development and progression of EC. EC and PR are involved in the development and progression of EC. The lower the expression level of ER and PR in EC, the lower the differentiation of tumor, The worse the prognosis.