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目的探讨2型糖尿病(T2DM)患者胰岛β细胞分泌功能分级标准,对T2DM诊治提供科学依据。方法选择T2DM患者219例,对空腹血糖(FPG)、糖化血红蛋白(HbAlc)、胰岛素的峰值(P INS)及与基础值的比值(Ip/Io)、C-肽峰值(Pc-p)及与基础值的比值(Cp/Co)等指标进行整理分析,拟定T2DM患者胰岛β细胞分泌功能分级标准。结果依据P INS、Ip/Io、Pc-p及Cp/Co等多项指标,T2DM患者胰岛β细胞分泌功能可分为三级:Ⅰ级(轻度异常)、Ⅱ级(中度异常)、Ⅲ级(重度异常)。结论胰岛β细胞分泌功能分级对指导T2DM患者临床诊治具有重要的理论意义和实际应用价值。
Objective To investigate the classification criteria of pancreatic β-cell secretion in patients with type 2 diabetes mellitus (T2DM) and provide a scientific basis for the diagnosis and treatment of T2DM. Methods Two hundred and ninety-two patients with T2DM were enrolled in this study. The levels of fasting blood glucose (FPG), HbA1c, P INS, basal ratio (Ip / Io), C-peptide peak Basal value ratio (Cp / Co) and other indicators to analyze and formulate the T2DM pancreatic β-cell secretory function grading standards. Results According to the indexes of P INS, Ip / Io, Pc-p and Cp / Co, the pancreatic β-cell secretory function of T2DM patients can be divided into three grades: Ⅰ grade (mild abnormal), Ⅱ grade Grade Ⅲ (severe abnormalities). Conclusion The classification of pancreatic β-cell secretory function has important theoretical and practical value in guiding the clinical diagnosis and treatment of T2DM patients.