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骨骼肌收缩和舒张活动是靠Na+—K+泵提供能量来完成的。Na+—K+泵是位于细胞膜上的一种特殊的蛋白质,它在酶的催化下发生反应,为骨骼肌的收缩和舒张提供能量。现证实Na+—K+泵主要功能单位是一个α-β亚单位多聚体蛋白质,在α亚单位上具有一个催化酶的活性,酶的活性需要一个与之相伴的β亚单位,目前认为运动可使Na+—K+泵数量增加,这可能与基因表达和泵降解速度减慢有关。每一肌纤维类型对于运动又有不同的反应。从mRNA的研究中发现运动使红—Ⅰ/Ⅱa肌泵和白—Ⅱa/Ⅱb肌泵数量增加,并引起rnRNA的增加,这说明运动使骨骼肌Na+—K+泵总数增加,同时也提高红—Ⅰ肌的αⅠ-mRNA和白—Ⅱb的β2—mRNA的数量,为肌肉的活动提供了物质基础。在运动开始时,使原先的mRNA进行翻译,合成新的蛋白质,随着运动继续,又可以进行mRNA的转录,使运动得以维持。
Skeletal muscle contraction and relaxation activities are carried out by the Na + -K + pump energy to complete. Na + -K + pump is a special protein located on the cell membrane. It catalyzes the enzyme reaction and provides energy for the contraction and relaxation of skeletal muscle. It is confirmed that the main functional unit of Na + -K + pump is an α-β subunit multimeric protein that has a catalytic enzyme activity on the α subunit. The activity of the enzyme requires an accompanying β subunit. At present, it is thought that exercise Increasing the number of Na + -K + pumps may be related to the slowdown of gene expression and pump degradation. Each muscle fiber type has a different response to exercise. From the study of mRNA, it was found that exercise increased the number of red-Ⅰ / Ⅱa muscle pump and white-Ⅱa / Ⅱb muscle pump and caused the increase of rnRNA, which indicated that the exercise increased the total number of Na + -K + pumps in skeletal muscle and also increased the red- Ⅰ muscle Ⅰ Ⅰ-mRNA and white-Ⅱ b β2-mRNA, the number of muscle activity provides the material basis. At the beginning of the exercise, the original mRNA is translated and a new protein is synthesized. As the exercise continues, transcription of the mRNA can be performed to maintain the exercise.