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新生儿肺部炎症是新生儿常见的呼吸系统疾病,近年来研究发现其发病与黏附分子CD11b/CD18的作用密切相关。CD11b/CD18是黏附分子中132整合素的一种,主要表达于单核-巨噬细胞、粒细胞、NK细胞等,可介导肺泡巨噬细胞对革兰阴性细菌及其胞壁成分脂多糖的吞噬作用,同时分泌白介素-1β(IL-1β)、IL-8等细胞因子。CD11b/CD18还与选择素、IL-8等共同介导了中性粒细胞从血循环向炎症灶的运动过程。结合新生儿本身特点,研究CD11b/CD18在新生儿肺部炎症中的作用,将有助于认识新生儿肺部炎症发生、发展和转归的内在机制,并为临床应用提供理论依据。
Neonatal pulmonary inflammation is a common respiratory disease in newborns, recent studies found that the incidence of CD11b / CD18 adhesion molecules are closely related. CD11b / CD18 is a type of adhesion molecule 132 integrin, mainly expressed in monocytes - macrophages, granulocytes, NK cells, can mediate the alveolar macrophages against Gram-negative bacteria and its cell wall components of lipopolysaccharide Phagocytosis, while secrete interleukin -1β (IL-1β), IL-8 and other cytokines. CD11b / CD18 together with selectins, IL-8 and other mediators of neutrophils from the blood circulation to the inflammatory lesions of the motility process. Combined with the characteristics of the newborn, the study on the role of CD11b / CD18 in neonatal lung inflammation will help to understand the intrinsic mechanism of neonatal pulmonary inflammation, development and prognosis, and provide a theoretical basis for clinical application.