３个月龄ＳＤ雌性大鼠６４只，双侧卵巢切除（ＯＶＸ）及行假手术（Ｓｈａｍ－Ｏ）；于术后第１，３，５，７个月各处死８只动物，切取Ｌ１～Ｌ２椎体节段，股骨及胫骨，进行ＢＭＤ检测结果ＯＶＸ后第１个月椎体ＢＭＤ明显丢失（Ｐ＜００１），全股骨丢失较为缓慢，７月时ＢＭＤ丢失才有差异（Ｐ＜００５）而股骨近段ＢＭＤ则自３月时丢失即有差异性（Ｐ＜００５）全胫骨１月ＢＭＤ即有差异性（Ｐ＜００５），３月时ＢＭＤ有回升（Ｐ＜００５），继之持续丢失，上段松质骨区则呈持续丢失结果提示：鼠ＯＶＸ后ＢＭＤ的丢失速度为腰椎＞胫骨＞股骨；腰椎体＞胫骨上段＞股骨上段 Sixty-three female SD rats of 3 months old, ovariectomized (OVX) and sham-operated (OVX) were performed. Eight animals were sacrificed at 1, 3, 5 and 7 months after operation, L2 vertebral segment, femur and tibia. RESULTS BMD of vertebral body was significantly decreased at 1 month after OVX (P <001), the loss of total femur was relatively slow, and there was a difference in BMD loss in July (P <005)  The BMD of the proximal femur was different from that of the femur in March (P <005). The BMD of the whole tibia was different in January (P <005). In March, the BMD (P <005), followed by continued loss of the upper cancellous bone area continued to be lost  Results suggest that: the loss of BMD after the OVX rat lumbar spine> tibia> femur; lumbar spine> upper tibia> the upper femur 