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固体药物在超临界二氧化碳(SC-CO_2)中溶解度的大小,对采用超临界技术制备药物超细微粒方法的选择上有重要意义。本试验采用动态法测定了苯扎贝特在纯SC-CO_2及含夹带剂(无水乙醇、丙酮、乙酸乙酯)的SC-CO_2中的溶解度。结果表明,在试验温度(308.15~328.15 K)和压力(10~30 MPa)下,苯扎贝特在纯SC-CO_2中的溶解度随温度和压力的升高而增大。夹带剂的加入有利于提高苯扎贝特的溶解度,其中无水乙醇效果尤其显著。采用Chrastil模型对试验结果进行拟合,结果表明Chrastil模型有较好的效果,相对偏差绝对值的平均值(AARD)为12.44%。
The solubility of solid drug in supercritical carbon dioxide (SC-CO_2) is of great significance for the selection of the method of preparing superfine particles by using supercritical technology. In this experiment, the solubility of bezafibrate in pure SC-CO_2 and SC-CO_2 containing entrainer (absolute ethanol, acetone, ethyl acetate) was determined by dynamic method. The results showed that the solubility of bezafibrate in pure SC-CO_2 increased with the increase of temperature and pressure at the test temperature (308.15 ~ 328.15 K) and pressure (10 ~ 30 MPa). Addition of entraining agent is helpful to improve the solubility of bezafibrate, especially the effect of absolute ethanol. The Chrastil model was used to fit the test results. The results showed that the Chrastil model had a good effect. The mean relative deviation (AARD) was 12.44%.