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本研究运用遗传流行病学病例对照方法，对常州市３４９个家系（１８３个ＮＩＤＤＭ先证家系和１６６个对照家系）进行了分离比、多基因遗传方式和遗传度的分析，以探讨遗传因素在ＮＩＤＤＭ病因中的地位。结果表明：在病例和对照具有良好均衡可比性的前提下，ＮＩＤＤＭ的分离比为０．０８３，显著低于０．２５，说明其不符合单基因遗传病的特征；遗传度的估算表明，ＮＩＤＤＭ一级亲属的遗传度为３６．２％，其中男性亲属的遗传度为４５．４％，高于女性亲属的３６．２％，说明在ＮＩＤＤＭ的病因中，遗传因素起着重要的作用；多基因遗传方式的分析表明，在遗传度为３６．２％时，ＮＩＤＤＭ一级亲属的理论发病率为３．９８％，与实际发病率３．４７％相比，无统计学显著差异（Ｐ＞０．０５），符合多基因遗传的特征。本次研究阐述了遗传因素在糖尿病病因中的地位，为有效地预防和控制糖尿病发生提供理论依据。
In this study, the genetic epidemiological case-control method was used to analyze the segregation ratio, polygenetic inheritance and heritability of 349 pedigrees (183 NIDDM probands and 166 control pedigrees) in Changzhou City, NIDDM cause of the status. The results showed that the isolation ratio of NIDDM was 0.083, which was significantly lower than 0.25 on the premise of a well-balanced comparability of cases and controls, indicating that it was not consistent with the characteristics of single-gene inheritance disease. The estimation of heritability showed that NIDDM The heritability of first-degree relatives was 36.2%, of which male heritages were 45.4%, higher than female relatives 36.2%, indicating that in the cause of NIDDM, genetic factors play an important role; more Analysis of genetic patterns showed that the theoretical incidence of first-degree relatives of NIDDM was 3.98% when the heritability was 36.2%, which was not significantly different from the actual incidence of 3.47% (P> 0.05), in line with the characteristics of multi-gene inheritance. This study describes the status of genetic factors in the etiology of diabetes, in order to effectively prevent and control diabetes provide a theoretical basis.