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选择煤工尘肺患者68例(壹期36例、贰期24例、叁期8例)和对照组38例,放免法检测甲状腺激素:血清总三碘甲腺原氨酸(TT3)、血清总甲状腺素(TT4)、血清游离三碘甲腺原氨酸(FT3)、促甲状腺激素(TSH);并检测肺通气功能:肺活量(VC)、用力肺活量(FVC)、一秒钟用力呼气量占预计值百分比(FEV1%)、25%与50%肺活量时呼气流速(V.25、V.50)、最大通气量(MVV)。结果贰+叁期组TT3、TT4降低,TSH增高,分别与对照组、壹期组比较差异具有统计学意义(P<0.05)。煤工尘肺各组肺通气功能指标均低于对照组(P<0.05),贰+叁期组肺通气功能指标均低于壹期组(P<0.05),差异具有统计学意义。煤工尘肺各组肺通气功能异常率均明显高于对照组(P<0.05),贰+叁期组肺通气功能异常率高于壹期组(P<0.05),差异具有统计学意义。提示煤工尘肺患者随期别增加和肺功能损害程度加重,甲状腺功能发生改变。
Sixty-eight patients (36 cases in one stage, 24 cases in stage II and 8 cases in stage II) and 38 cases in control group were selected for thyroid hormone (TT) Thyroid hormone (TT4), serum free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) were measured. Ventilatory function was measured: vital capacity (VC), forced vital capacity (FVC), forced expiratory volume (FEV1%), expiratory flow (V.25, V.50), and maximum ventilation (MVV) at 25% and 50% vital capacity. Results The levels of TT3, TT4 decreased and TSH increased in the second and third trimester groups compared with the control group and the first phase group (P <0.05). The indexes of lung ventilation in each group were lower than those in the control group (P <0.05). The indexes of pulmonary ventilation in the second and third groups were all lower than those in the first group (P <0.05). The difference was statistically significant. The pneumoconiosis function abnormalities in each group were significantly higher than those in the control group (P <0.05). The abnormality rate of pulmonary ventilation in the second and third groups was higher than that in the first group (P <0.05). The difference was statistically significant. Prompted coal workers with pneumoconiosis with increased risk of lung damage and increased, thyroid function changes.