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目的探讨丁二磺酸腺苷蛋氨酸治疗淤积型病毒性肝炎临床应用和疗效。方法选取鹰潭市人民医院铁路分院在2010年1月~2012年12月收治的淤胆型病毒性肝炎患者60例,所有患者均符合临床通用的病毒性肝炎的诊断标准,且经实验室检查明确诊断为淤胆型肝炎,将所有患者随机分为观察组和对照组,对照组采用常规保胆、降酶治疗,观察组在常规治疗的基础上加用丁二磺酸腺苷蛋氨酸治疗,对2组的治疗效果进行比较。结果疗效的比较,观察组总有效率(93.3%)显著大于对照组(76.7%)(P<0.05);治疗前后2组患者肝功能指标的比较,治疗前2组差异无统计学意义,治疗后观察组ALT、AST、TBil、DBil、TBA指标的下降幅度均明显优于对照组(P<0.05)。治疗过程中2组患者均未出现不良反应。结论在常规保胆治疗的基础上加用丁二磺酸腺苷蛋氨酸治疗淤积型病毒性肝炎患者疗效确切,可明显改善患者的临床症状,且无不良反应,安全性高,值得临床推广。
Objective To investigate the clinical application and efficacy of adenosine methionine butane sulfonate in the treatment of patients with viral hepatitis. Methods Sixty patients with cholestatic hepatitis were admitted from January 2010 to December 2012 in the Railway Branch of People’s Hospital of Yingtan City. All patients were in line with the diagnostic criteria of clinical viral hepatitis and were confirmed by laboratory tests The diagnosis of cholestatic hepatitis, all patients were randomly divided into observation group and control group, the control group using conventional gallbladder, enzyme-lowering treatment, the observation group on the basis of conventional treatment with adenosine methionine treatment, 2 groups of treatment were compared. The results showed that the total effective rate (93.3%) in the observation group was significantly higher than that in the control group (76.7%) (P <0.05). There was no significant difference in the liver function indexes between the two groups before and after treatment, After the observation group ALT, AST, TBil, DBil, TBA decreased significantly than the control group (P <0.05). No adverse reactions occurred in both groups during the course of treatment. Conclusion Addition of adenosine methionine butane disulfonate is effective in treating patients with silicosis due to conventional gallbladder therapy, which can significantly improve the clinical symptoms of patients without adverse reactions and is safe and worthy of clinical promotion.