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目的 探讨糖耐量异常 (IGT)诊断标准的临床意义。方法 16 2例实验者依据血糖水平分为三组 ,第Ⅰ组为血糖对照组 73例 ,口服糖耐量试验 (OGTT)糖负荷后 2h血糖低于 7 0mmol/L ;第Ⅱ组 4 2例 ,OGTT糖负荷后 2h血糖为 7 0～ 7 8mmol/L ;第Ⅲ组 4 7例 ,为OGTT糖负荷后 2h血糖为 7 9～ 11 1mmol/L。进行糖耐量试验并检测血脂水平和尿清蛋白排泄率。结果 Ⅱ组对象UAER明显高于Ⅰ组和Ⅲ组 (P <0 0 1) ,低密度脂蛋白和总胆固醇 (Ⅱ、Ⅲ组高于Ⅰ组 ,P <0 0 5 ) ,但Ⅱ、Ⅲ组间无差异 ;其他指标三组间无明显差异。Ⅰ组、Ⅱ组和Ⅲ组异常心电图分别为 1%、8%、4 %。结论 从预防糖尿病的并发症考虑 ,将血糖水平在 7 0～ 7 8mmol/L的对象 (Ⅱ组 )归入IGT组可能是实用的。
Objective To investigate the clinical significance of the diagnostic criteria of impaired glucose tolerance (IGT). Methods Twenty-two subjects were divided into three groups according to the level of blood glucose. The first group was 73 cases of blood glucose control group. The blood sugar of oral glucose tolerance test (OGTT) was lower than 70mmol / L at 2h; the second group was 42 cases, OGTT glucose load 2h after 2h blood glucose 70 ~ 7 8mmol / L; group Ⅲ 4 47 cases, 2 hours after OGTT glucose load blood glucose 7 9 ~ 11 1mmol / L. Glucose tolerance test and blood lipid levels and urinary albumin excretion rate were measured. Results The UAER of group Ⅱ was significantly higher than that of group Ⅰ and Ⅲ (P <0.01), low density lipoprotein and total cholesterol (group Ⅱ and Ⅲ were higher than group Ⅰ, P <0 05) No difference between the other indicators of the three groups no significant difference. The abnormal electrocardiogram of group Ⅰ, Ⅱ and Ⅲ were 1%, 8% and 4% respectively. Conclusions To prevent the complication of diabetes mellitus, it may be practical to classify subjects with blood glucose levels between 70 and 78 mmol / L (group Ⅱ) into the IGT group.