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目的探讨围手术期食管癌患者血浆D-dimer水平的变化规律,评估发生血栓的风险。方法随机选取行手术治疗的29例食管癌患者为癌症组,同期开胸的12例良性病变患者为对照组,测定两组患者术前、术后3d、术后9d的血浆D-dimer水平,与其病理学特征及手术方式进行统计学分析。结果术后D-dimer在对照组(P<0.001)和癌症组(P<0.001)中均升高,但在癌症组中升高趋势明显(P<0.001)。癌症组中,血浆D-dimer在术后3d较术前升高显著,在术后9d升高趋于平缓。围手术期食管癌患者D-dimer水平改变与病理类型(P=0.64)、病理分级(P=0.84)、TNM分期(P=0.52)、手术方式(P=0.83)均无关。结论食管癌患者术后血浆D-dimer变化明显,术后可能并发血栓的风险也较高。
Objective To investigate the changes of plasma D-dimer level in perioperative esophageal cancer patients and assess the risk of thrombosis. Methods Twenty-nine patients with esophageal cancer who underwent surgery were selected as the cancer group. Twelve patients with benign lesions underwent thoracotomy during the same period were selected as the control group. The plasma D-dimer levels were measured before and 3 days after operation and 9 days after operation. With its pathological features and surgical methods for statistical analysis. Results Postoperative D-dimer increased in the control group (P <0.001) and cancer group (P <0.001), but increased significantly in the cancer group (P <0.001). In the cancer group, the plasma D-dimer increased significantly 3 days after operation and tended to be gentle on the 9th day after operation. The change of D-dimer level in perioperative patients with esophageal cancer was not related to pathological type (P = 0.64), pathological grade (P = 0.84), TNM stage (P = 0.52) and surgical method (P = 0.83) Conclusions Postoperative plasma D-dimer changes significantly in patients with esophageal cancer, and the risk of postoperative thrombosis is also high.