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近年来,国内外对再障的基础理论研究进展较快,对再障的发病机理主要从造血干细胞,造血微环境和免疫调节三方面进行了大量深入的研讨。认为造血干细胞缺损,造血微环境缺陷和免疫调节障碍(所谓“种子”、“土壤”和“虫害”)三者相互作用的结果是引起再障的主要机理。骨髓造血干细胞是各种血细胞的始祖。当再障患者骨髓造血干细胞的分化与繁殖受到某种因素的
In recent years, the basic theory of aplastic anemia at home and abroad is progressing rapidly, and the pathogenesis of aplastic anemia is mainly studied in three aspects: hematopoietic stem cells, hematopoietic microenvironment and immune regulation. It is thought that the main mechanism of aplastic anemia is the result of the interaction between hematopoietic stem cell defects, hematopoietic microenvironmental defects and immunomodulatory disorders (so-called “seeds”, “soils” and “pests”). Bone marrow hematopoietic stem cells are the ancestor of various blood cells. When aplastic anemia in patients with bone marrow hematopoietic stem cell differentiation and propagation of certain factors