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同种免疫性血小板减少症是由母亲的抗体通过胎盘引起的。该抗体直接对抗胎儿血小板上的特异性抗原。临床表现为无症状至大量颅内出血。脐带穿刺术已用于同种免疫性血小板减少症患者以诊断胎儿血小板减少症、监控药物治疗的反应,并可作胎儿血小板分型。一般认为脐带穿刺后可发生胎儿死亡,但很少。而一次同种免疫性血小板减少症产前治疗的国际试验报道,取样操作后胎儿死亡数异常升高。
Alloimmune thrombocytopenia is caused by the mother’s antibodies passing through the placenta. This antibody directly targets specific antigens on fetal platelets. Clinical manifestations of asymptomatic to a large number of intracranial hemorrhage. Umbilical cord aspiration has been used in patients with alloimmune thrombocytopenia to diagnose fetal thrombocytopenia, monitor the response to drug therapy, and make fetal platelet typing. Generally believed that fetal death after umbilical cord puncture, but rarely. An international trial of prenatal treatment of alloimmune thrombocytopenia has reported an abnormal increase in the number of fetal deaths after sampling.