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目的评价持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床疗效和安全性。方法将82例应激性溃疡新生儿分为对照组40例与试验组42例。对照组予以奥美拉唑0.8 mg·kg-1·d-1,每天1次,连续使用3 d;试验组给予奥美拉唑2 mg·kg-1,24 h持续微泵滴注治疗。比较2组患者的临床疗效、治疗前后胃液p H值及不良反应发生率。结果治疗后,试验组的总有效率为92.86%,对照组为87.50%(P>0.05),但试验组显效率(52.38%)显著高于对照组(27.50%,P<0.05)。治疗后,2组p H值水平均显著高于治疗前(P<0.05),且试验组治疗后p H值显著高于对照组(P<0.05)。2组治疗过程中均未见药物相关不良反应发生。结论持续微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床疗效显著,优于常规给药方式。
Objective To evaluate the clinical efficacy and safety of continuous low-dose micro-pump infusion of omeprazole in the treatment of neonatal stress ulcer. Methods Eighty-two neonates with stress ulcer were divided into control group (n = 40) and experimental group (n = 42). The control group was given omeprazole 0.8 mg · kg-1 · d-1 once a day for 3 consecutive days. The experimental group was given omeprazole 2 mg · kg-1,24 h by continuous micro-pump infusion. The clinical efficacy of the two groups were compared, p H value of gastric juice before and after treatment and the incidence of adverse reactions. Results After treatment, the total effective rate was 92.86% in the experimental group and 87.50% in the control group (P> 0.05). However, the effective rate in the experimental group was significantly higher than that in the control group (27.50%, P <0.05). After treatment, the levels of p H in the two groups were significantly higher than those before treatment (P <0.05), and p H values in the experimental group were significantly higher than those in the control group after treatment (P <0.05). No adverse drug reactions occurred in the two groups during the course of treatment. Conclusion Continuous micro-pump infusion of omeprazole treatment of neonatal stress ulcer clinical efficacy was significantly better than the conventional mode of administration.