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胃粘膜上皮不典型增生系指腺管及上皮细胞在增生过程中所出现的形态结构和功能的异常现象。不典型增生包括两种含义,即在炎症、糜烂或溃疡等胃粘膜病变时上皮细胞的异型增生,以及近似胃癌的“交界性”不典型增生。一般来说,后者细胞、组织结构的不典型或异型的程度更严重。仅依靠病理特征要将这两种不典型增生以及它们同分化型癌鉴别常有困难,为探索重度不典型增生与胃癌的关系,我们前瞻性地开展了这一临床研究。
Gastric epithelium atypical hyperplasia refers to the abnormal structure and function of glandular and epithelial cells during the process of proliferation. Atypical hyperplasia includes two meanings, namely, dysplasia of epithelial cells in gastric mucosal lesions such as inflammation, erosions or ulcers, and “junctional” dysplasia that approximates gastric cancer. In general, the degree of atypical or heterotypic cell and tissue structure of the latter is more serious. Only relying on pathological features to identify these two types of dysplasia and their differentiation with differentiated carcinoma often difficult to explore the relationship between severe dysplasia and gastric cancer, we carried out this clinical study prospectively.