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目的调查分析妇科肿瘤患者围手术期抗菌药物的使用情况,为合理使用抗菌药物提供参考数据。方法查阅2015年1月~6月妇科肿瘤患者符合围手术期要求的1066份病历,进行回顾性研究。结果围手术期妇科肿瘤患者抗菌药物的总使用率为98.78%;单药使用为术前用药的主要方式,占术前给药总病例的99.33%;二联用药为术后主要给药方式(占术后71.70%),主要以硝基咪唑类联合头孢米诺、哌拉西林舒巴坦最为常见;给药时机主要为术前30 min至术前2 h,占术前给药病例的96.96%;Ⅰ类切口抗菌药物使用率为80.88%,Ⅱ~Ⅳ类切口抗菌药物使用率均为100.00%;Ⅱ类切口占总病例数的87.05%,该类中68.53%预防用药时长在大于48 h至5 d范围之间。结论围手术期抗菌药物的使用存在不合理现象,应加强和规范围手术期抗菌药物的应用及管理。
Objective To investigate the use of perioperative antibiotics in patients with gynecologic cancer and provide reference data for rational use of antimicrobial agents. Methods One hundred and sixty-six cases of gynecologic oncology patients who met perioperative requirements from January to June in 2015 were reviewed retrospectively. Results The total usage of antimicrobial agents was 98.78% in patients with perioperative gynecologic oncology. The single drug was the main method of preoperative medication, accounting for 99.33% of the total cases preoperatively administered. The two drugs were the main mode of administration Accounting for 71.70% post-operatively), and the most common ones were nitroimidazole combined with cefminox and piperacillin and sulbactam. The timing of the administration was mainly from 30 minutes before operation to 2 hours before operation, accounting for 96.96 cases %; The incision type Ⅰ antibacterial drug usage rate was 80.88%, the Ⅱ ~ Ⅳ type incision antibacterial drug utilization rate was 100.00%; type Ⅱ incision accounted for 87.05% of the total number of cases, 68.53% of the class of preventive medication longer than 48 h To 5 d range. Conclusion There is an irrational use of antimicrobial agents during perioperative period. The application and management of perioperative antibacterials should be strengthened and regulated.