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目的探讨食管鳞癌组织中脆性组氨酸三联体(FHIT)基因的表达及其临床意义。方法应用免疫组织化学SP法检测FHIT在37例食管鳞癌组织及10例癌旁组织中的表达。结果食管鳞癌组织中FHIT蛋白阳性表达率43.2%显著低于癌旁组90.0%(P<0.05)。食管鳞癌高、中分化组FHIT蛋白阳性表达率52.9%显著高于低分化组36.4%(P<0.05);淋巴结转移患者FHIT蛋白阳性表达率显著低于无淋巴转移组46.4%νs55.6%(P<0.05)。结论 FHIT基因在食管鳞癌的发生、发展中起重要作用,对其蛋白的检测可作为判定食管鳞癌发生及转移能力的一项客观指标。
Objective To investigate the expression of FHIT gene in esophageal squamous cell carcinoma and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of FHIT in 37 cases of esophageal squamous cell carcinoma and 10 cases of paracancerous tissues. Results The positive rate of FHIT protein in esophageal squamous cell carcinoma was 43.2%, which was significantly lower than that in adjacent noncancerous tissues (90.0%, P <0.05). The positive expression rate of FHIT protein in high and moderately differentiated squamous cell carcinoma group was 52.9%, which was significantly higher than that in poorly differentiated group (36.4%, P <0.05). The positive expression rate of FHIT protein in lymph node metastasis was significantly lower than that in non-lymphatic metastasis group (46.4% vs 55.6% (P <0.05). Conclusion FHIT gene plays an important role in the occurrence and development of esophageal squamous cell carcinoma. The detection of its protein can be used as an objective index to determine the occurrence and metastasis of esophageal squamous cell carcinoma.