丹皮酚显著抑制豚鼠Forssman皮肤血管炎反应,大鼠反向皮肤过敏反应,大鼠主动和被动Arthus型足跖肿胀;丹皮酚对绵羊红细胞、牛血清白蛋白诱导的小鼠迟发型足跖肿胀,对二硝基氟苯引起的小鼠接触性皮炎均有明显的抑制作用。实验表明,丹皮酚并不显著影响特异性抗体的形成,但可选择性地抑制补体经典途径的溶血活性,还可调节细胞免疫功能。 Paeonol markedly inhibited guinea pig Forssman cutaneous vasculitis, skin anaphylaxis in rats, and active and passive Arthus paw edema in rats. Paeonol had no effect on sheep erythrocytes and bovine serum albumin induced delayed footing Swelling, the dinitrofluorobenzene-induced mouse contact dermatitis were significantly inhibited. Experiments show that paeonol does not significantly affect the formation of specific antibodies, but can selectively inhibit the hemolysis of classical complement pathway, but also regulate cellular immune function.