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[Objective] To further detect the active components and functions of Solanum cathayanum,since previous research showed that it had relatively good antioxidant activity. [Methods] After extraction,isolation and structural identification,the antioxidant protection activity of scopolin from Solanum cathayanum to the damaged SH-SY5 Y cells was researched,which was induced by H2O2. [Results] Far from the toxicity range,scopolin showed similar antioxidant activity like positive control VE; and the LDH leakage rate reduced significantly,showing that scopolin reduced the membrane damage. Besides,0. 1 μmol / m L scopolin was helpful to enhance the contents of SOD and GSH. [Conclusions] Scopolin could be developed and used for the research on drugs for neurodegenerative diseases.
To further detect the active components and functions of Solanum cathayanum, since previous research showed that it had relatively good antioxidant activity. [Methods] After extraction, isolation and structural identification, the antioxidant protection activity of scopolin from Solanum cathayanum to the damaged SH-SY5 Y cells was researched, which was induced by H2O2. [Results] Far from the toxicity range, scopolin showed similar antioxidant activity like positive control VE; and the LDH leakage rate reduced significantly, showing that scopolin reduced the membrane damage. , 0.1 μmol / m L scopolin was helpful to enhance the contents of SOD and GSH. [Conclusions] Scopolin could be developed and used for the research on drugs for neurodegenerative diseases.