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目的研究养阴降糖片对糖尿病模型大鼠血糖的影响。方法建立四氧嘧啶致糖尿病大鼠模型,将大鼠随机分为5组(n= 10),分别用高、中、低剂量养阴降糖片和0.9%氯化钠溶液(0.1ml/10g体重)灌胃14d。14d后测定正常大鼠的血糖水平,并在相应时间测定四氧嘧啶致糖尿病大鼠模型空腹血糖(FBG)、药后2h血糖(2hBG)、胰岛素水平,同时对四氧嘧啶所致糖尿病大鼠进行胰腺病理组织学检查。结果养阴降糖片对正常大鼠血糖水平无影响,能够显著降低四氧嘧啶模型大鼠空腹血糖(与模型组比较降糖率可达25.11%,P<0.05～0.01)和药后2hBG(P<0.05),明显提高胰岛素水平(P<0.05～0.01)。结论养阴降糖片对四氧嘧啶引起的高血糖有显著的降血糖作用。
Objective To study the effect of Yangyin Jiangtang Tablet on blood glucose in diabetic model rats. METHODS: A rat model of alloxan-induced diabetes was established. Rats were randomly divided into 5 groups (n = 10) and treated with high-, medium-, and low-dose Yangyin Jiangtang tablets and 0.9% sodium chloride solution (0.1ml/10g). Body weight) gavage 14d. After 14 days, the blood glucose levels of normal rats were measured, and the fasting blood glucose (FBG), 2h blood glucose (2hBG), and insulin levels after alloxan-induced diabetic rats were measured at the corresponding time, and alloxan-induced diabetic rats were also given. Pancreatic histopathology was performed. Results Yangyin Jiangtang Tablet had no effect on the blood glucose level of normal rats, and it could significantly reduce the fasting blood glucose of alloxan-induced model rats (25.11% compared with the model group, P<0.05-0.01) and 2hBG after drug administration. P<0.05), significantly increased insulin levels (P<0.05-0.01). Conclusion Yangyin Jiangtang Tablets has a significant hypoglycemic effect on alloxan-induced hyperglycemia.