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目的:评价和比较腹腔结核6个月短程化疗与12个月标准疗程的治疗效果。设计和对象:共193名确诊腹腔结核的成年病人随机分配到2个不同的每日治疗方案中:1)6个月短程化疗组,前2个月使用利福平、异烟肼和吡嗪酰胺,后4个月使用利福平和异烟肼(简称6R组),2)12个月标准疗程组,使用乙胺丁醇和异烟肼以及为期2周的链霉素补充治疗(简称12E组)。仅对疑及肠梗阻和肠穿孔的病人施行手术。结果:除30人因各种原因退出外,总共对163人(6R组85人,12E组78人)进行了疗效分析。治疗结束时临床状态恢复正常者6R组有84人(99％),12E组有73人(94％)。其中147人随访5年,无一因腹腔结核复发而需要治疗。结论:在治疗各型腹腔结核中6个月短疗程化疗组的疗效与12个月标准疗程组同样有效。
OBJECTIVE: To evaluate and compare the therapeutic effect of 6 months short-course chemotherapy and 12-month standard treatment of abdominal tuberculosis. DESIGN AND OBJECTIVES: A total of 193 adult patients diagnosed with celiac tuberculosis were randomly assigned to 2 different daily treatment regimens: 1) 6-month short-course chemotherapy with rifampin, isoniazid and pyrazine in the first 2 months Amide, rifampicin and isoniazid after 4 months (referred to as 6R group), 2) 12-month standard course of treatment with ethambutol and isoniazid plus 2-week streptomycin supplementation (referred to as 12E ). Only patients suspected of bowel obstruction and intestinal perforation surgery. Results: A total of 163 patients (85 in 6R and 78 in 12E) were enrolled in this study, except for 30 exits for various reasons. The clinical status returned to normal at the end of treatment in 84 patients (99%) in group 6R and 73 (94%) in group 12E. 147 of them were followed up for 5 years, and none of them needed treatment because of recurrent abdominal tuberculosis. CONCLUSIONS: The efficacy of a 6-month short-course chemotherapy in the treatment of various types of abdominal tuberculosis was as effective as the 12-month standard treatment group.