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目的观察放疗中同时应用盐酸川芎嗪注射液预防放射性肺损伤的作用。方法将病理确诊初次接受放疗的肺癌或食管癌患者98例随机分为放疗联合川芎嗪组(研究组)和放疗未联合川芎嗪组(对照组),两组各49例。研究组在放疗期间静脉滴注盐酸川芎嗪80 mg/次,1次/d,对照组未配合川芎嗪治疗。放疗结束后3、12个月统计急性及晚期放射性肺损伤发生率。结果研究组、对照组急性放射性肺损伤分别为18.4%,40.8%,研究组、对照组晚期放射性肺损伤分别为23.4%,55.3%,差异有统计学意义(P<0.05)。结论放疗中同时应用盐酸川芎嗪能减少放射性肺损伤的发生。
Objective To observe the role of simultaneous administration of Ligustrazine Hydrochloride Injection to prevent radiation-induced lung injury during radiotherapy. Methods Ninety-nine patients with lung cancer or esophageal cancer who underwent initial radiotherapy were randomly divided into radiotherapy and ligustrazine group (study group) and radiotherapy without ligustrazine group (control group), 49 cases in each group. The study group intravenous infusion of ligustrazine hydrochloride 80 mg / time, 1 time / d during radiotherapy, the control group did not cooperate with ligustrazine treatment. 3 and 12 months after the end of radiotherapy, the incidence of acute and advanced radiation-induced lung injury was calculated. Results The acute radiation-induced lung injury in study group and control group was 18.4% and 40.8%, respectively. The incidence of late-stage radiation-induced lung injury in study group and control group was 23.4% and 55.3% respectively, with significant difference (P <0.05). Conclusions The simultaneous application of Ligustrazine Hydrochloride in radiotherapy can reduce the incidence of radiation-induced lung injury.