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报道了“一锅法”合成含两种桥联链的新型杯[4]双冠醚和双杯[4]冠醚.杯[4]芳烃先与N,N’-乙撑基-二(2-氯乙酰胺)发生“1+1”缩合反应,然后直接加入三甘醇双对甲苯磺酸酯继续进行“2+2”缩合反应,合成了含两种桥联链的新型双杯[4]冠醚4.按照相似程序,杯[4]芳烃先后与N,N’-乙撑基-二(2-氯乙酰胺)、溴乙酸乙酯和二乙烯三胺反应,得到含两种桥联链的新型杯[4]双冠醚5.化合物5进一步与异硫氰酸苯酯反应合成带硫脲支链的杯[4]双冠醚6.所有新化合物的结构与构象经元素分析、质谱、核磁共振谱等表征证实.
A new method for the synthesis of new calix [4] diazepine and double-calix [4] crown ethers containing two bridging chains was reported. “Calix [4] (2-chloroacetamide) ”1 + 1“ condensation reaction, and then directly added triethylene glycol bis-tosylate continue ”2 +2 " condensation reaction was synthesized containing two kinds of bridge Chain [4] crown ethers 4. Following a similar procedure, the calix [4] arene was reacted with N, N’-ethyne-bis (2-chloroacetamide), ethyl bromoacetate and diethylenetriamine To give a new calix [4] bis-crown ether containing two bridging chains 5. Compound 5 was further reacted with phenylisothiocyanate to synthesize calix [4] diazonium chloride with thiourea branches 6. All new compounds The structure and conformation were confirmed by elemental analysis, mass spectrometry and nuclear magnetic resonance spectroscopy.