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目的:观察蝎毒多肽提取物(PESV)对H22肝脏原位移植瘤模型小鼠肝脏NK细胞表达及功能的影响。方法:C57BL/6小鼠肝脏接种H22肝癌细胞株悬液构建原位移植瘤模型,术后给予PESV大、小剂量及生理盐水灌胃,14 d后检测肝脏及浸润癌组织中NK细胞及穿孔素、颗粒酶B的表达变化并观察小鼠生存期。结果:PESV大、小剂量组肝脏移植瘤的生长受到抑制,肿
Objective: To observe the effects of scorpion venom peptide extract (PESV) on the expression and function of liver NK cells in orthotopic liver transplantation (H22) mice. Methods: C57BL / 6 mice were inoculated with H22 hepatoma cell suspension to establish orthotopic transplantation tumor model. After operation, PESV was given to large and small doses and normal saline. After 14 days, NK cells and perforation in liver and invasive carcinoma were detected Changes in the expression of granzyme B and the survival of mice were observed. Results: The growth of liver xenografts in PESV large and small dose groups was inhibited and swollen