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目的:研究中药“养肺方”联合氩氦刀冷冻治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效。方法:收集自2012年6月至2015年6月期间老年晚期NSCLC并接受氩氦刀冷冻治疗患者共130例,分为中西医结合组65例(“养肺方”+最佳对症治疗)和西医治疗组65例(最佳对症支持),评价其近期疗效(影像学评价、生活质量评价)和生存获益[总生存期(OS)、术后生存期和无进展生存期(PFS)]。结果:1影像学评价:两组氩氦刀治疗的手术部位、病灶大小及手术次数、术中CT影像监测评价及有效率比较,差异均无统计学意义,两组接受氩氦刀手术情况具有可比性;2生活质量(QOL)比较:中西医结合组术后3个月QOL评分为(47.85±2.78),与西医治疗组同期(46.15±3.43)比较明显提高(P<0.01);3远期疗效:中西医结合组术后生存期为14个月,OS为23个月;西医治疗组术后生存期为12个月,OS为21个月,中西医结合组术后生存期和OS均比西医治疗组稍长,但差异无统计学意义;中西医结合组PFS为7个月,比西医治疗组(5个月)长(P<0.05)。结论:养肺方联合氩氦刀冷冻治疗老年晚期NSCLC近期能提高患者生活质量,远期在延长PFS方面表现出优势,是值得进一步研究和推广的治疗模式。
Objective: To study the clinical effect of traditional Chinese medicine “Yangfei Recipe” combined with argon-helium cryoablation in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: A total of 130 elderly patients with NSCLC admitted to our hospital from June 2012 to June 2015 were enrolled in this study. They were divided into two groups: 65 cases in Integrative Medicine group ) And western medicine group (65 cases), and evaluated its short-term curative effect (imaging evaluation, quality of life evaluation) and survival benefit (OS, postoperative survival and progression-free survival )]. RESULTS: 1 Imaging evaluation: There was no significant difference in the surgical site, the size of the lesion, the number of operations, the monitoring and evaluation of the CT images and the effective rate between the two groups in the treatment of argon-helium knife. There was Comparing the quality of life (QOL): The QOL score of the integrated traditional Chinese and western medicine group was (47.85 ± 2.78) 3 months after operation, significantly higher than that of the western medicine treatment group (46.15 ± 3.43) (P <0.01); 3 The effect of treatment: The survival time of the integrated traditional Chinese and western medicine group was 14 months and the OS was 23 months. The Western medicine treatment group had a survival time of 12 months and an OS of 21 months. The postoperative survival and OS PFS was 7 months in the Integrative Medicine group, which was longer than that in the western medicine treatment group (5 months) (P <0.05). Conclusion: Yangfei Recipe combined with argon-helium cryoablation can improve the quality of life of elderly patients with advanced NSCLC in the near future. Prolongation has the advantage in prolonging PFS, which is worth to be further studied and popularized.