Objective:To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe（益肾祛风胜湿方,YQSR) in patients with glomerular proteinuda.Methods:A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group (108 cases) and the control group (37 cases) according to a random number table in a ratio of 3:1.All patients received conventional and symptomatic treatment.In addition,patients in the treatment and control groups were given YQSR (200 mL,twice per day,orally) and Iosartan (50 mg/d orally),respectively for 6 months.The 24-h udne protein quantity,blood urea nitrogen,and serum creatinine in the two groups were measured at multiple time points before and after treatment.Results:At the end of the study,5 cases were lost to follow-up in the treatment group and 1 in the control group.Finally,the statistical data included 103 cases in the treatment group and 36 cases in the control group.The total effectiveness after 2,4,and 6 months was 81.6％ (84/103),87.4％ (90/103),and 92.2％ (95/103),respectively,in the treatment group and 47.2％ (17/36),55.6％ (20/36),and 61.1％ (22/36),respectively,in the control group,with significant difference between the two groups (P＜0.01 at all observation points).In the treatment group,the curative effect after 6 months was better than that after 2 months (P＜0.05).The 24-h udne protein quantity was significantly lower in the treatment group at 3,4,5,and 6 months than that in the control group (P＜0.05 or P＜0.01,respectively).Conclesion:YQSR could significantly reduce the amount of glomerular proteinuda in the eady stage.