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转化医学是近年来国际医学界引起广泛关注的新概念,提倡以最直接有效的方式把医学相关联的基础研究快速转化为临床医学应用技术,同时临床医学的应用效果及新的临床观察又以最快的速度反馈到相关的基础研究中,这样,在医学相关的基础研究和临床医学应用之间形成快速良性互动。这个新时代的到来,为与医学密切相关的药学特别是药物创制提出了新的挑战。本文结合几个实例,就转化医学背景下药物创制思路、手段和方法做一简述。
Translational medicine is a new concept that attracts wide attention in the international medical community in recent years. It advocates the rapid and effective conversion of basic medical research into clinical application technology. At the same time, the clinical application of clinical medicine and new clinical observations Fastest speed feeds back into relevant basic research, thus creating a fast and benign interaction between medical-related basic research and clinical medicine applications. The advent of this new era poses new challenges for the development of pharmaceuticals, especially pharmaceuticals, which are closely related to medicine. Combined with a few examples, this article makes a brief introduction of the ideas, means and methods of drug creation under the background of transforming medicine.