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目的探讨CC族趋化因子受体7(CCR7)和CXC族趋化因子受体4(CXCR4)在肺癌组织中的表达及临床意义。方法采用免疫组织化学检测72例肺癌组织标本和30例良性肺疾病肺组织标本中CXCR4和CCR7的表达情况,并分析其不同临床病理特征中表达的差异。结果 CCR7和CXCR4在肺癌组织中的表达阳性率均明显高于正常肺组织,差异有统计学意义(P<0.01);CCR7和CXCR4表达与肺癌患者的TNM分期,纵膈淋巴结转移密切相关(P<0.01),与年龄、性别、病例组织学类型等均无关(P>0.05),并且Spearman相关分析显示,CXCR4表达与CCR7表达呈高度正相关(r=0.623,P<0.001)。结论 CXCR4和CCR7在肺癌纵膈淋巴转移中发挥重要作用。
Objective To investigate the expression and clinical significance of CC chemokine receptor 7 (CCR7) and CXC chemokine receptor 4 (CXCR4) in lung cancer. Methods The expression of CXCR4 and CCR7 in 72 lung cancer specimens and 30 lung specimens from patients with benign lung disease were detected by immunohistochemistry. The differences in the expression of CXCR4 and CCR7 in different clinicopathological features were analyzed. Results The positive rates of CCR7 and CXCR4 in lung cancer tissues were significantly higher than those in normal lung tissues (P <0.01). The expressions of CCR7 and CXCR4 were closely related to TNM stage and mediastinal lymph node metastasis in lung cancer patients (P (P <0.05). Spearman correlation analysis showed that CXCR4 expression was positively correlated with CCR7 expression (r = 0.623, P <0.001). Conclusion CXCR4 and CCR7 play an important role in the mediastinal lymph node metastasis of lung cancer.