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目的评价血清胱抑素C检测在原发性高血压患者中的应用价值,并观察坎地沙坦对其的影响。方法选择50例原发性高血压患者,并以50例健康人做为对照,分别测定血清胱抑素C(Cys-C)、尿β2-微球蛋白(β2-MG)、血肌酐(Cr)、尿素氮(BUN)水平。然后给予50例高血压患者坎地沙坦8 mg/d服用,4周后重复测量上述指标。结果高血压患者中血清Cys-C和尿β2-MG的值较正常对照组明显升高(P<0.01)。经坎地沙坦治疗后,血清Cys-C和尿β2-MG均明显下降(P<0.01,P<0.05),而Cr、BUN无明显变化。结论血清Cys-C可以作为原发性高血压早期肾功能损害的诊断指标之一,坎地沙坦可以降低血清Cys-C水平,延缓肾功能损害。
Objective To evaluate the value of serum cystatin C in patients with essential hypertension and to observe the effect of candesartan on it. Methods Fifty patients with essential hypertension were enrolled in this study. Fifty healthy subjects were enrolled in this study. Serum levels of cystatin C (Cys-C), urinary β2-microglobulin (β2-MG), serum creatinine ), Urea nitrogen (BUN) levels. Then given 50 patients with hypertension candesartan 8 mg / d, 4 weeks after repeated measurement of these indicators. Results Serum levels of Cys-C and urinary β2-MG in hypertensive patients were significantly higher than those in normal controls (P <0.01). After treatment with candesartan, serum Cys-C and urinary β2-MG were significantly decreased (P <0.01, P <0.05), while Cr and BUN had no significant changes. Conclusions Serum Cys-C can be used as a diagnostic indicator of early renal damage in patients with essential hypertension. Candesartan can reduce serum Cys-C and delay renal dysfunction.