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生长分化因子15(GDF-15)是细胞因子超家族转化生长因子-β中的成员。在生理条件下GDF-15在心肌中呈弱表达,而在诸多病理条件下其表达水平增加。越来越多的证据表明,GDF-15水平升高是心血管疾病的一种很有价值的预后标志物。此外,GDF-15对心肌细胞具有内源性抗肥厚和拮抗心脏缺血/再灌注损伤的性质。GDF-15正在成为评估和管理心脏病患者的一种很有前途的生物学标志物,并对心肌细胞具有潜在的保护作用。
Growth Differentiation Factor 15 (GDF-15) is a member of the cytokine superfamily transforming growth factor-β. Under physiological conditions, GDF-15 is weakly expressed in the myocardium and its expression is increased under various pathological conditions. There is growing evidence that elevated GDF-15 is a valuable prognostic marker of cardiovascular disease. In addition, GDF-15 possesses endogenous anti-hypertrophic and anti-cardiac ischemic / reperfusion injury to cardiomyocytes. GDF-15 is emerging as a promising biomarker for the assessment and management of heart disease and has potential protective effects on cardiomyocytes.