在真核细胞中 ,ＤＮＡ与组蛋白是染色质的主要成分。染色质结构与基因活性密切相关 ,通过组蛋白乙酰化和去乙酰化来修饰染色质的结构 ,在ＤＮＡ复制、基因转录及细胞周期的调控等方面有重要作用[1 ] 。各种肿瘤的发生过程中常伴有乙酰化紊乱 ,干预组蛋白乙酰化可影响肿瘤的进程 In eukaryotes, DNA and histones are the major components of chromatin. Chromatin structure and gene activity are closely related to histone acetylation and deacetylation to modify the chromatin structure, in DNA replication, gene transcription and cell cycle regulation plays an important role [1]. A variety of tumors often accompanied by acetylation during the disorder, the intervention of histone acetylation can affect the progress of the tumor