论文部分内容阅读
目的探讨急性心肌梗死(AMI)患者N末端B型钠尿肽(NT-proBNP)水平与梗死后短期心力衰竭的关系。方法将80例AMI患者分为心力衰竭组和非心力衰竭组,测定入院时及入院后24 h、7 d的血浆NT-proBNP浓度及超声心动图检查的左室射血分数(LVEF)及左室舒张末内径(LVEDD),出院随访30 d。结果心力衰竭组血浆24 h、7 d NT-proBNP水平持续增高,两组在入院即刻及入院24 h、7 d时血浆NT-proBNP水平比较差异有统计学意义(P<0.01)。NT-proBNP水平与LVEF呈负相关(P<0.05),与LVEDD呈显著正相关(r=0.452,P<0.01)。结论血浆NT-proB-NP水平是心肌梗死后早期发生心力衰竭的预测因子,并有预后判断价值。
Objective To investigate the relationship between the level of N-terminal B-type natriuretic peptide (NT-proBNP) and short-term heart failure after acute myocardial infarction (AMI). Methods Eighty patients with AMI were divided into two groups: heart failure group and non-heart failure group. Plasma NT-proBNP concentrations at admission, 24 h and 7 d after admission were measured, left ventricular ejection fraction (LVEF) and left ventricular ejection fraction The end-diastolic diameter (LVEDD) was followed up for 30 days. Results The levels of NT-proBNP in plasma of 24 h and 7 d in heart failure group were continuously increased. There was significant difference in plasma NT-proBNP level between the two groups immediately after admission and 24 h and 7 d after admission (P <0.01). The level of NT-proBNP was negatively correlated with LVEF (P <0.05) and positively correlated with LVEDD (r = 0.452, P <0.01). Conclusion The plasma NT-proB-NP level is a predictor of heart failure in the early post-MI period and has prognostic value.