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动脉粥样硬化是一种慢性血管壁炎症性疾病，导致血管损伤或斑块的形成，其特征是炎性细胞浸润。冠状动脉粥样硬化性心脏病（冠心病）是由冠状动脉粥样硬化致心肌缺血缺氧或坏死而引起的心脏病。目前有很多研究证实，冠心病与炎性因子和免疫有关，而与炎症和免疫有关的因子很多。目前有一些新的生物指标如：组织蛋白酶K、脂蛋白相关磷脂酶 A2、缺血修饰白蛋白、和肽素等。这些因子对冠心病的预后和危险分层等起着重要的作用。“,”Atherosclerosis is a chronic inflammatory disorder of the vessel wall ,resulting in formation of vascular lesions,or plaques,which are characterised by inflammation .Coronary heart disease is a clinical syn-drome which caused by myocardial ischemia or necrosis .There are many studies have confirmed coronary heart disease is associated with inflammation and immunity,there are many inflammatory factors.At present, there are some novel biomarkers such as:cathepsin K,lipoprotein associated phospholipase A2(Lp-PLA2), Ischemia Modiffied Albumin(IMA),and copeptin.These factors play an important role in the prognosis of coronary heart disease and risk stratification .