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目的探讨尿毒症患者维持性血液透析(MHD)动脉粥样硬化及其危险因素的研究。方法选择在血透室治疗的 MHD 患者30例,健康体检者21名为对照组,进行颈动脉高频彩色多普勒超声检查,测量血清 C 反应蛋白(CRP),肿瘤坏死因子(TNF)a,血糖(GIU),白蛋白(ALB)浓度及钙磷乘积,对病例组及对照组诸指标进行分析。结果病例组与对照组比较,颈动脉内膜-中层厚度(IMT),CRP,TNFa 钙磷乘积(Ca×P)均明显增高,ALB 则明显降低,GIU 两者差异无显著性。结论尿毒症血液透析患者颈动脉硬化与炎症的营养不良状态具有相关性,后者是前者的危险因素。
Objective To investigate the maintenance hemodialysis (MHD) atherosclerosis in uremic patients and its risk factors. Methods Thirty patients with MHD and twenty-one healthy subjects were selected as control group. High-frequency color Doppler ultrasonography was performed on carotid artery to measure the levels of serum C-reactive protein (CRP), tumor necrosis factor , Blood glucose (GIU), albumin (ALB) concentration and calcium and phosphorus products, and analyzed the indexes of case group and control group. Results Compared with the control group, carotid intima - media thickness (IMT), CRP, Ca and P of TNFa (Ca × P) were significantly increased, ALB was significantly decreased, and GIU had no significant difference. Conclusions There is a correlation between carotid atherosclerosis and inflammatory malnutrition in uremic hemodialysis patients, which is the former risk factor.