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目的通过对孕中期(孕15～20周)母血清中游离β-hcG和AFP检测,研究血清标志物与某些产科并发症的关系,以期早期发现,早期诊断产科并发症。方法对妊娠15～20周孕妇,抽取静脉血,检测AFP和fβ-hcg。结果当游离β-hcGMoM值≥2.0时,孕中期高水平AFPMoM值与早产、低体重儿、前置胎盘、新生儿窒息有关;当AFPMoM值在0.5～2.0时,孕中期高水平fβ-hcGMoM值与羊水过少,羊水污染,过期妊娠,胎窘,胎盘植入有关;当游离β-hcGMoM值在0.5～2.0时,孕中期高水平AFPMoM值与重度子痫前期、胎膜早破、前置胎盘有关。结论孕中期高水平血清标志物与一些产科并发症如早产、低体重儿、前置胎盘、胎盘植入、胎膜早破、羊水过少、羊水污染、胎儿宫内窘迫、新生儿窒息、子痫前期有关。
Objective To investigate the relationship between serum markers and some obstetric complication by detecting the free β-hcG and AFP in the second trimester of pregnancy (15-20 weeks gestation) in order to detect and diagnose the obstetric complications early. Methods For pregnant women of 15-20 weeks of gestation, venous blood was drawn for the detection of AFP and fβ-hcg. Results When the free β-hcGMoM value was ≥2.0, the high second trimester AFPMoM level was associated with preterm birth, low birth weight infants, placenta previa, and neonatal asphyxia. When the AFPMoM was between 0.5 and 2.0, the second trimester high level of fβ-hcGMoM And amniotic fluid pollution, outdated pregnancy, fetal distress, placenta accreta related; when free β-hcGMoM value of 0.5 to 2.0, the second trimester high level of AFPMoM value and severe preeclampsia, premature rupture of membranes, pre Placental related. Conclusions The high levels of serum metabonomia in the second trimester are associated with some obstetric complications such as preterm birth, low birth weight, placenta previa, premature rupture of membranes, oligohydramnios, amniotic fluid contamination, fetal distress, neonatal asphyxia, Related to preeclampsia.