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目的:探讨移植肾组织穿刺活检的临床指导意义。方法:对50例肾移植后出现血清肌酐超过正常、蛋白尿、肾小球性血尿等且依据临床资料不能确诊病因者进行移植肾组织活检,并对病理学诊断与分类进行分析。结果:病理学检查确诊慢性排斥反应20例,其中7例病理检查提示同时存在急性排斥反应;急性排斥反应10例,肾小管药物毒性8例,系膜增生性肾炎4例,IgA肾病3例,加速性排斥反应2例,急性肾小管坏死2例,膜性肾病1例。结论:移植肾组织活检安全、可靠,可为临床移植肾疾病的诊断提供可靠组织学和细胞学依据,有助于临床正确诊断及治疗。
Objective: To investigate the clinical significance of transplanted renal biopsy. Methods: 50 cases of renal transplant recipients with serum creatinine more than normal, proteinuria, glomerular hematuria, etc., and based on clinical data can not be diagnosed cause transplant kidney biopsy, and pathological diagnosis and classification were analyzed. Results: Twenty cases of chronic rejection were diagnosed by pathology examination. Seven of the pathological examination showed simultaneous acute rejection; 10 cases of acute rejection, 8 cases of renal tubular toxicity, 4 cases of mesangial proliferative glomerulonephritis, 3 cases of IgA nephropathy, Acceleration of rejection in 2 cases, 2 cases of acute tubular necrosis, membranous nephropathy in 1 case. Conclusion: The biopsy of transplanted kidney tissue is safe and reliable, which can provide reliable histological and cytological evidence for the diagnosis of clinical transplant kidney disease, which is helpful for the correct diagnosis and treatment in clinic.