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目的 探讨促性腺激素释放激素激动剂(GnRH-a)延长给药间隔周期治疗子宫腺肌病及子宫内膜异位症疗效的影响.方法 选取2014年1月至2016年1月在惠州市第一人民医院接受治疗的子宫内膜异位症及子宫腺肌病患者104例,将患者随机分为对照组52例和实验组52例.对照组按传统治疗方法给予治疗,疗程24周,每4周注射3.75 mg曲普瑞林,共6次;实验组疗程也为24周,总用量减少两次,即每6周注射3.75 mg曲普瑞林,共4次.观察两组患者治疗前后的血清性激素水平、痛经程度和子宫体积的变化.结果 经过治疗后两组患者VRS评分和子宫体积均明显下降,与治疗前比较差异有统计学意义(P<0.05),且实验组效果更加显著,治疗后两组比较差异有统计学意义(P0.05);治疗后6、12、24周两组患者血清性激素的水平均明显下降,与治疗前比较差异有统计学意义(P0.05).结论 GnRH-a延长给药间隔与传统方案一样能够达到治疗子宫内膜异位症和子宫腺肌病的效果,都能够抑制雌激素水平,运用此方法能够明显降低治疗费用.“,”Objective To investigate the effect of gonadotropin-releasing hormone agonist(GnRH-a)prolonging the interval of treatment for the treatment of adenomyosis and endometriosis. Methods 104 patients with endometriosis and adenomyosis were enrolled in this study from January 2014 to 2016. Patients were randomly divided into two groups:control group(n=52)received treatment according to traditional therapy ,every 4 weeks injection of 3.75 mg triptorelin ,a total of 6 times;experimental group of 52 patients,treatment for 24 weeks,the total amount reduced twice,that is,every 6 weeks injection of 3.75 mg triptorelin ,a total of 4 times. The levels of serum sex hormones ,dysmenorrhea and uterine volume were observed before and after treatment in both groups. Results After treatment ,the VRS score and uterine volume of the two groups were significantly decreased ,and the difference was statistically significant (P<0.05),and the experimental group was more effective,the difference between the two groups was statistically significant(P0.05). The levels of serum sex hormones decreased significantly at 6 weeks,12 weeks and 24 weeks after treatment(P0.05). Conclusion GnRH-a prolonged drug delivery interval could achieve the same effect as traditional regimen for the treatment of endometriosis and adenomyosis,and could inhibit low estrogen. This method can significantly reduce the cost of treatment.