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~(99m)锝-甲溴苯宁(~(99m)Tc-mebrofenin)为一较新的放射性肝胆显像药物。本文通过动物实验和临床试用,证明其毒性小,使用安全,肝胆特异性高。与其他同类肝胆显像剂相比较,静脉注射~(99m)锝-甲溴苯宁后更为迅速地被肝脏摄取、分泌并经由胆道系统排入肠道;它与胆红素的竞争能力更强,肝脏通过时间短,胆汁中分泌量多且泌尿系排出量小,因而肝、胆影像清晰且能应用于高胆红素血症病例。本组病例血清胆红素最高达28mg％,临床试用结果满意。~(99m)锝-甲溴苯宁是较为理想的放射性肝胆显像剂,值得在临床推广使用。
99m Tc-mebrofenin is a relatively new radiopharmaceutical agent for hepatobiliary imaging. In this paper, animal experiments and clinical trials to prove its toxicity, safety, hepatobiliary specificity. Compared with other similar hepatobiliary imaging agents, 99m-technetium-methylbromide injected intravenously is more rapidly taken up by the liver, secreted and discharged into the intestine through the biliary system. Its competitiveness with bilirubin is even greater Strong, the liver through a short time, bile secretion and urinary excretion and small, so the liver and gallbladder images clear and can be applied to cases of hyperbilirubinemia. Serum bilirubin in this group of patients up to 28mg%, clinical trial results were satisfactory. ~ (99m) technetium - methylbromide is the ideal radioactive hepatobiliary imaging agent, it is worth to promote the use of the clinic.