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严重感染及与之相关的并发症是多器官功能衰竭和死亡的常见原因。细菌和真菌的感染反应部分是病原体间接作用的结果。间接作用发生于刺激宿主巨噬细胞后,导致一系列细胞素的产生,诸如TNF、IL-1、IL-6和干扰素α。虽然这些物质可提高宿主的局部防御能力,但其播散却引起感染的全身反应。氧化亚氮在内皮、巨噬、脑神经、中性、枯否和肝细胞内合成。内毒素、TNF、IL-1和干扰素γ是氧化亚氮合成的有力促进剂。L-精氨酸在哺乳动物
Serious infections and their associated complications are a common cause of multiple organ failure and death. Part of the bacterial and fungal infection response is the result of an indirect pathogen. Indirect effects occur after stimulation of host macrophages, resulting in the production of a series of cytokines such as TNF, IL-1, IL-6 and interferon alpha. Although these substances enhance the local defense ability of the host, their spreading causes systemic reactions to the infection. Nitrous oxide is synthesized in the endothelium, macrophages, cranial nerves, neutral, Kupffer cells and hepatocytes. Endotoxin, TNF, IL-1 and interferon gamma are potent promoters of nitrous oxide synthesis. L-arginine in mammals