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对１２例持续非卧床腹膜透析（ＣＡＰＤ）维持一年以上和１６例维持一年以上血液透析的慢性肾衰透析患者（其中９例合并高血压），用放射免疫分析测定血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）和甲状旁腺素（ＰＴＨ）的水平，以观察经ＨＤ和ＣＡＰＤ的慢性肾衰患者血浆ＥＴ、ＡＮＰ和ＰＴＨ的变化。慢性肾衰患者血浆ＥＴ、ＡＮＰ和ＰＴＨ浓度均较对照组显著升高，而透析８周前、后差异不显著，合并高血压的透析患者ＥＴ、ＡＮＰ和ＰＴＨ较对照组显著升高，但与无高血压的透析组比，差异也不显著。结果表明ＥＴ、ＡＮＰ和ＰＴＨ在慢性肾衰的发病机制中起重要作用，但ＣＡＰＤ与ＨＤ对ＥＴ、ＡＮＰ和ＰＴＨ水平的影响无明显差异。
Twelve patients with persistent renal dialysis (CAPD) who had been on CPD for more than one year and 16 patients who had maintained hemodialysis for more than one year (including 9 patients with hypertension) were assayed for plasma endothelin (ET) by radioimmunoassay. (ANP) and parathyroid hormone (PTH) levels in patients with chronic renal failure of HD and CAPD to observe the changes of plasma ET, ANP and PTH. The levels of plasma ET, ANP and PTH in patients with chronic renal failure were significantly higher than those in the control group, but there was no significant difference between before and after dialysis for 8 weeks. The ET, ANP and PTH in patients with hypertension and dialysis were significantly higher than those in the control group No hypertension in the dialysis group, the difference is not significant. The results showed that ET, ANP and PTH played an important role in the pathogenesis of chronic renal failure, but the effects of CAPD and HD on ET, ANP and PTH levels had no significant difference.