论文部分内容阅读
目的探讨Tourette综合征(TS)发病的危险因素。方法2000-01—2004-12采用病例对照研究的方法,对温州医学院附属一院100例TS患儿及100名对照病例的相关资料进行非条件Logistic回归和主成分分析。结果非条件Logistic回归多因素分析显示,该病有统计学显著性意义的危险因素是TS家族史、注意缺陷伴多动障碍(ADHD)、过敏性哮喘、母亲孕早期受精神刺激、高热(T>39℃)和极低频磁场暴露,其标准回归系数分别为1.3987、3.6385、1.7657、1.7250、1.8973和1.0677。主成分分析提取了4个主成分,其方差累积贡献率为57.025%。结论TS的发病与遗传因素和环境因素有关。
Objective To investigate the risk factors of Tourette’s syndrome (TS). Methods From 2000-01-2004-12, a case-control study was conducted to investigate the non-conditional Logistic regression and principal component analysis of the related data of 100 children with TS in the First Affiliated Hospital of Wenzhou Medical College and 100 control cases. Results In non-conditional Logistic regression multivariate analysis, the risk factors for the disease were statistically significant family history of TS family history, attention deficit hyperactivity disorder (ADHD), allergic asthma, mothers in the first trimester by mental stimulation, high fever (T > 39 ℃) and very low frequency magnetic field exposure, the standard regression coefficients were 1.3987, 3.6385, 1.7657, 1.7250, 1.8973 and 1.0677 respectively. Principal component analysis extracted four principal components, the cumulative contribution rate of variance 57.025%. Conclusion The incidence of TS is related to genetic factors and environmental factors.