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【目的】评价晚期早产儿(34～36+6周)中,在生后2 h内给予静脉补充氨基酸的效果和安全性。【方法】将115例患儿随机分为两组,治疗组在生后2 h内给予静脉输注氨基酸[2.4 g/(kg.d)],对照组则在生后第1天仅给予输注葡萄糖治疗,在第3天逐渐增加到氨基酸2.4 g/(kg.d)。并动态测定患儿的血气、血糖、BUN及氮平衡情况。【结果】治疗组患儿的BE和HCO3-在生后的第2、4天均低于对照组(P<0.05或0.01)。生后第2天血糖监测显示对照组较治疗组偏高(P<0.05)。治疗组生后第2、4天的血尿素氮水平明显高于对照组(P<0.01)。生后第2天,治疗组的氮平衡明显高于对照组(P<0.05),并且对照组呈负氮平衡。【结论】对晚期早产儿早期补充高剂量氨基酸是安全的,使机体处于合成代谢状态,为生长发育所必需。
【Objective】 To evaluate the efficacy and safety of intravenous amino acid supplementation within 2 hours after birth in advanced preterm infants (34-36 + 6 weeks). 【Methods】 One hundred and fifteen children were randomly divided into two groups. The treatment group received intravenous infusion of amino acid [2.4 g / (kg · d)] within 2 hours after birth and the control group received only infusion Note Glucose treatment, increasing gradually to amino acid 2.4 g / (kg.d) on the third day. And dynamic determination of children’s blood gas, blood glucose, BUN and nitrogen balance situation. 【Results】 BE and HCO3- in the treatment group were lower than those in the control group on the 2nd and 4th days after birth (P <0.05 or 0.01). On the second day after birth, blood glucose monitoring showed that the control group was higher than the treatment group (P <0.05). Blood urea nitrogen levels in the treatment group were significantly higher than those in the control group on the 2nd and 4th days after birth (P <0.01). On the second day after birth, the nitrogen balance of the treatment group was significantly higher than that of the control group (P <0.05), and the control group showed negative nitrogen balance. 【Conclusion】 It is safe to add high doses of amino acids to the early stage of advanced premature infants, making the body in the state of anabolism and metabolism, which is necessary for growth and development.