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[目的]研究非糜烂性胃食管反流病(NERD)患者的胃食管反流事件,为进一步探讨NERD发病机制和有效治疗提供临床依据。[方法]68例NERD患者进行食管阻抗-pH监测,根据监测结果、症状指数,分为病理性酸反流(PAR)组、功能性烧心(FH)组、高敏性食管(HE)组,比较3组间反流事件的差异,研究反流与症状之间的相关性。[结果]PAR组总反流次数、酸反流次数、混合反流次数均高于FH组、HE组;HE组总反流次数、弱酸反流次数、混合反流次数、非酸反流次数均高于FH组;各组近段反流次数比较差异无统计学意义。68例中35例(51.5%)SI和(或)SAP呈阳性,其中50%的症状与弱酸反流相关,40%的症状与酸反流相关,少部分症状与非酸反流相关。[结论]PAR、FH、HE患者的食管阻抗-pH监测结果存在差异,可为临床鉴别诊断和治疗提供一定的依据。
[Objective] To study the gastroesophageal reflux disease in patients with non-erosive gastroesophageal reflux disease (NERD) and provide a clinical basis for further exploring the pathogenesis and effective treatment of NERD. [Methods] Sixty-eight NERD patients underwent esophageal impedance-pH monitoring. According to the monitoring results and symptom indices, the patients were divided into three groups: pathological acid reflux (PAR), functional heartburn (FH) and hypersensitivity esophagus The differences in reflux events among the 3 groups studied the correlation between reflux and symptoms. [Results] The total number of reflux, the number of acid reflux and the number of mixed reflux in PAR group were higher than those in FH group and HE group. The total number of reflux, the number of weak acid reflux, the number of mixed reflux, Were higher than the FH group; the number of proximal reflux group was no significant difference. Of the 68 patients, 35 (51.5%) were positive for SI and / or SAP, 50% of them were related to weak acid reflux, 40% were related to acid reflux and a few were related to non-acid reflux. [Conclusion] The results of esophageal impedance-pH monitoring in patients with PAR, FH and HE are different, which may provide some evidences for clinical differential diagnosis and treatment.